MTP Kit-Mifegest

Mifegest is a pharmaceutical product used primarily for medical abortion (termination of pregnancy) and the management of certain gynecological conditions. It contains the active ingredient Mifepristone, a synthetic steroid that acts as a progesterone receptor antagonist. Mifegest is widely used in combination with another medication called Misoprostol to ensure the complete termination of an early pregnancy.

Key Details About Mifegest:

1. Active Ingredient:

• Mifepristone (200 mg or 400 mg tablets):
  • Mifepristone works by blocking the action of progesterone, a hormone essential for maintaining the lining of the uterus during pregnancy. Without progesterone, the uterine lining breaks down, and the pregnancy cannot continue.

  • 2. Indications:

    • Medical Termination of Pregnancy (MTP):
      • Mifegest is used to terminate early pregnancies (up to 10 weeks gestation or 70 days from the first day of the last menstrual period).
    • Management of Miscarriage:
      • It can be used to manage incomplete or missed miscarriages.
    • Cervical Ripening:
      • In some cases, Mifegest is used to soften and dilate the cervix before surgical procedures like dilation and curettage (D&C).
    • Other Uses:
      • Occasionally prescribed for conditions like Cushing’s syndrome or uterine fibroids, though this is less common.

    ---

    3. Mechanism of Action:

    • Mifegest blocks progesterone receptors, leading to:
      • Breakdown of the uterine lining.
      • Detachment of the embryo.
      • Softening and dilation of the cervix.
    • When combined with Misoprostol (a prostaglandin analog), it induces uterine contractions, which help expel the pregnancy tissue.

    ---

    4. Dosage and Administration:

    • Step 1: A single dose of Mifegest (200 mg or 400 mg) is taken orally under medical supervision.
    • Step 2: After 24-48 hours, Misoprostol (800 mcg) is administered either orally or vaginally to induce uterine contractions and complete the abortion process.
    • Follow-Up: A follow-up visit after 7-14 days is essential to confirm the completion of the abortion and rule out complications.

    ---

    5. Effectiveness:

    • When used correctly, Mifegest in combination with Misoprostol has a success rate of over 95% for terminating early pregnancies.
    • The effectiveness decreases slightly as the pregnancy progresses closer to 10 weeks.

    ---

    6. Side Effects:

    • Common Side Effects:
      • Nausea, vomiting, diarrhea, abdominal pain, dizziness, and fatigue.
      • Vaginal bleeding (similar to or heavier than a menstrual period) and cramping are expected as part of the process.
    • Less Common Side Effects:
      • Headache, fever, or chills.
    • Rare but Serious Side Effects:
      • Heavy or prolonged bleeding (requiring medical attention).
      • Incomplete abortion (requiring surgical intervention).
      • Infection or allergic reactions.

    ---

    7. Contraindications:

    • Mifegest should not be used in the following cases:
      • Pregnancy beyond 10 weeks gestation.
      • Suspected ectopic pregnancy.
      • Chronic adrenal failure or long-term corticosteroid use.
      • Known allergy to Mifepristone or Misoprostol.
      • Hemorrhagic disorders or use of anticoagulants.
      • Presence of an intrauterine device (IUD) that has not been removed.

    ---

    8. Precautions:

    • Mifegest should only be used under the supervision of a qualified healthcare provider.
    • Patients must have access to emergency medical care in case of complications.
    • A follow-up visit is mandatory to ensure the abortion is complete and to monitor for complications.

    ---

    9. Storage:

    • Store at room temperature (15°C to 30°C or 59°F to 86°F).
    • Keep the tablets in their original packaging, away from moisture and direct sunlight.